Журнал Сибирского федерального университета
Journal of Siberian Federal University
Химия
Chemistry
Редакционный совет:
академик РАН Е.А. Ваганов
академик РАН И.И. Гительзон
академик РАН А.Г. Дегерменджи
академик РАН В.Ф. Шабанов
чл.-корр. РАН, д-р физ.-мат. наук
В.Л. Миронов
чл.-корр. РАН, д-р техн. наук
Г.Л. Пашков
чл.-корр. РАН, д-р физ.-мат. наук
В.В. Шайдуров
чл.-корр. РАН, д-р физ.-мат. наук
В.В. Зуев
Editorial Advisory Board
Chairman:
Eugene A. Vaganov
Members:
Josef J. Gitelzon
Vasily F. Shabanov
Andrey G. Degermendzhy
Valery L. Mironov
Gennady L. Pashkov
Vladimir V. Shaidurov
Vladimir V. Zuev
Editorial Board:
Editor-in-Chief
Mikhail I. Gladyshev
Founding Editor
Vladimir I. Kolmakov
Managing Editor
Olga F. Alexandrova
Executive Editor for Chemistry
Boris N. Kuznetsov
Ä.Â. Êóçüìèí, Â.È. Кузьмин
q%!Kц, ц"е2…/. ме2=лл%" ,ƒ C3льC .ел=2%…=м,
– 151 –
Н.Ю. Васильева, А.В. Левданский, А.С. Казаченко,
Л. Дьякович, К. Пинель, Б.Н. Кузнецов
q3ль-=2,!%"=…,е ме.=…%=*2,",!%"=……%г% =!=K,…%г=л=*2=…=
*%мCле*“%м “е!…/L =…г,д!,д $ C,!,д,… " “!еде C,!,д,…=
– 158 –
Редактор И.А. Вейсиг Корректор Е.Г. Иванова
Компьютерная верстка Е.В. Гревцовой
Подписано в печать 00.06.2013 г. Формат 84х108/16. Усл. печ. л. 9,2.
Уч.-изд. л. 8,9. Бумага тип. Печать офсетная. Тираж 1000 экз. Заказ 2007.
Отпечатано в ПЦ БИК СФУ. 660041 Красноярск, пр. Свободный, 82a.
CONTENTS / СОДЕРЖАНИЕ
Alexander D. Vasiliev and Nicolay N. Golovnev
Ciprofloxacinium Malonate Dihydrate: Preparation, Crystal
Structure, Thermal Stability
– 107 –
Abdulgalim B. Isaev, Naida K. Tajibova,
Farid F. Orudjev, Patimat M. Salikhova,
Ruslan V. Ilkanaev and Marat N. Medjidov
Photoelectrocatalytic and Photocatalytic Oxidation of Azodye at
High Oxygen Pressure
– 114 –
Â.È. Øàðûïîâ, È.Ï. Èâàíîâ, Î.Þ. Ôåòèñîâà,
Î.Ï. Òàðàí, Â.Ä. Страховенко, Á.Í. Кузнецов
h““лед%"=…,е 2е!м,че“*,. C!е"!=?е…,L “=C!%CелеL %ƒе!
j=ч*3ль… , a=!ч,… m%"%“,K,!“*%L %Kл=“2, ме2%д=м, dŠcdqj
, pt`
– 122 –
Â.Ì. Äåíèñîâ, Í.Â. Белоусова, Ë.Ò. Денисова
a%!=2/ ",“м32=
– 132 –
2013 6 (2)
Стр.1
Editorial board for Chemistry:
Nikolai V. Chesnokov
Lubov ’ K. Altunina
Natalia G. Bazarnova
Vasiliy A. Babkin
Vicente Cebolla
Viktor M. Denisov
Zinfer R. Ismagilov
Sergey V. Kachin
Sergey D. Kirik
Wolfgang Klose
Vladimir I. Kovalchuk
Vladimir A. Likholobov
Yuri L. Mikhlin
Gennady L. Pashkov
Anatoly I. Rubailo
Tatyana V. Ryazanova
Vladimir A. Sobyanin
Valeri E. Tarabanko
Tatyana G. Shendrik
Jean V. Weber
Ä.Ñ. Êàëÿêèí, Í.Ñ. Åëèñååâà,
Þ.Å. Àíàíüåâà, À.À. Êóçóáîâ, À.Î. Лыхин
j"=…2%"%-.,м,че“*%е ,ƒ3че…,е C!%це““= “%!Kц,, , м,г!=ц,,
=2%м= 3гле!%д= …= C%"е!.…%“2, г!=-е…= , K,г!=-е…=
– 170 –
ß.È. ßêèìîâ, Ñ.Ä. Êèðèê,
Å.Ñ. Ñåìåíêèí, Ë.À. Ñîëîâüåâ, È.Ñ. Якимов
}"%люц,%……/L ме2%д м%дел,!%"=…,
*!,“2=лл,че“*%L
“2!3*23!/ "е?е“2"= C% д=……/м C%!%ш*%"%L д,-!=*ц,,
– 180 –
С.А. Кузнецова, Т.П. Шахтшнейдер,
Ì.A. Ìèõàéëåíêî,Þ.Í. Ìàëÿð,
À.Ñ. Çàìàé, Â.Â. Болдырев
lе.=…%*%мC%ƒ,2 д,=це2=2= Kе23л,…= , ег% C!%2,"%%C3.%ле"=
=*2,"…%“2ь
– 192 –
А.К. Старков, Г.А. Кожуховская
q,…2еƒ , -,ƒ,*%-.,м,че“*%е ,““лед%"=…,е …е“,мме2!,ч…/.
*%мCле*“%" 2!=…“-д,.л%!%д,=м,…Cл=2,…/(II)
Свидетельство о регистрации СМИ
ПИ № ФС77-28-726 от 29.06.2007 г.
Серия включена в «Перечень ведущих
рецензируемых научных журналов
и изданий, в которых должны
быть опубликованы основные научные
результаты диссертации на
соискание ученой степени доктора и
кандидата наук» (редакция 2010 г.)
– 203 –
Ò.À. Ëåîíîâà, À.È. Äóäíèê,
Í.Ã. Âíóêîâà, È.Â. Îñèïîâà,
Ã.À. Ãëóùåíêî, Å.Â. Томашевич, Ã.Í. Чурилов
q!="…е…,е “%!Kц,%……%L ём*%“2, C% ,%…=м л,2, г!=-,2%"/.
, -3лле!е…-л,2,е"/. =…%д%"
– 210 –
Стр.2
Journal of Siberian Federal University. Chemistry 2 (2013 6) 107-113
~ ~ ~
УДК 548.737
Ciprofl oxacinium Malonate Dihydrate:
Preparation, Crystal Structure,
Thermal Stability
Alexander D. Vasilieva,b
and Nicolay N. Golovneva
a Siberian Federal University,
*
79 Svobodny, Krasnoyarsk, 660041 Russia
b
50/38 Akademgorodok, Krasnoyarsk, 660036 Russia
Ciprofl oxacinium malonate dihydrate (I), C17
CfH; C3
H4
O4
Received 14.11.2012, received in revised form 23.01.2013, accepted 11.02.2013
+·C3
H19
FN3
O3
H3
O4
−·H2
O, (C17
H18
FN3
O3
– ciprofl oxacin,
− malonic acid) has been crystallized from the mutual solution of malonic acid and
ciprofl oxacin in ambient conditions. It has improved aqueous solubility against the ciprofl oxacin.
The colourless crystals have been investigated using X-ray single crystal and powder techniques,
and characterized by differential scanning calorimetry and thermogravimetry. The obtained
compound can be considered as a salt with ciprofl oxacinium in the role of a cation and malonate
as an anion. The compound is crystallized in the triclinic lattice with a = 7.283(2), b = 10.090(3),
c = 15.104(5)Å, α = 102.711(4), β = 103.328(4), γ = 94.261(4)°, Z = 2, V = 1044.5(6)Å3
, S.G. P1. The
crystal structure determination reveals the importance of inter- and intramolecular interactions in
the crystal formation. Thermal behavior and solubility of I provided complementary evidences of
salt formation.
Keywords: ciprofl oxacinium malonate dihydrate, crystal structure, thermal behavior.
Ciprofl oxacin (CfH), 1-cyclopropyl-6-fl uoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic
acid, is a fl uoroquinolone antibiotic approved for the treatment of several types of infections [1].
In aqueous solutions CfH exists mainly in its zwitterionic form, due to the acid base interaction
between the piperazine basic nitrogen and the carboxylic group. As a consequence the aqueous
solubility of CfH at pHs close to 7 (isoelectric point of the molecule) is low (0.088 mg/ml) [2]. This
property makes it diffi cult to formulate optimized liquid dosage forms such as parenteral, ototopic
or ophthalmic solutions. Moreover, ciprofl oxacin is characterized by a bitter taste [3], which is an
additional complication for the oral administration of it. It has been proposed that CfH bioavailability
© Siberian Federal University. All rights reserved
* Corresponding author E-mail address: ngolovnev@sfu-kras.ru
# 107 #
Kirensky Institute of Physics SB RAS,
Стр.3