Autophagy is a process directed to recycle of cellular proteins and organelles for maintaining homeostasis in eukaryotic cells. <...> Recent evidence is supported by an important role of the autophagy pathway in the immune response modulation. <...> There are the two studies showing a positive association between genetic variants of autophagy-related genes with asthma have been published recently. <...> Here, we review the recent advances in asthma genetics. <...> Аутофагия – это процесс расщепления и рециркуляции внутриклеточных протеинов и органелл, обеспечивающий клеточный гомеостаз в эукариотических клетках. <...> Traditional asthma treatment goals include the decrease of infl ammation, improvement of lung function, the reduced number of clinical symptoms, hospitalizations and emergency department visits, the reduced number of school absences resulting from asthma [3]. <...> Allergic diseases clearly indicates a signifi cant genetic component, in which any of multiple gene variants can to contribute to the disease risk and infl uence allergic infl ammations. <...> Many case control studies have examined the association between one or more polymorphisms of a particular candidate gene and asthma phenotypes, with the candidate gene selected on the basis of its suspected role in the pathobiology of allergic diseases. <...> Single nucleotide polymorphism (SNP) is a substitution of one single nucleotide for another – the simplest form of DNA variations among individuals occurring throughout the genome at a frequency of about one in 1000 base pairs [4, 5]. <...> SNPs may infl uence promoter activity – gene expression, messenger RNA conformation (stability), subcellular localization of mRNAs or proteins. <...> Synonymous SNPs also can alter structure, function and expression levels of proteins and hence may be implicated in disease or medicinal drug metabolism [6]. <...> SNPs play a direct role in familial traits and phenotypic expression of the diseases [4, 7]. <...> Even if a disease-associated SNP is not discovered to be a causative agent, it often exists in linkage disequilibrium (nonrandom association of alleles at two or more loci) with the disease-causative allele, and can lead scientists to the functional risk variant, which can be hundreds of kilobases away [6]. <...> Nowadays, numerous genetic studies demonstrated a signifi cant association of SNPs in candidate genes with asthma and the asthma-associated phenotypes. <...> For example <...>