Днепропетровская медицинская академия Министерства здравоохранения Украины, Днепропетровск, Украина The comparison of clinical and immunologic effi cacy of diff erent methods of allergen-specifi c immunotherapy in children suff ering from pollinosis Сравнение клинической и иммунологической эффективности различных методов аллерген-специфической иммунотерапии у детей, страдающих поллинозом ______________________ Resume __________________________________________________________________________ The clinical and immunological effi cacy of allergen-specifi c immunotherapy (ASIT) by the allergen drugs in the form of subcutaneous injections and oral dragee in children, suff ering from pollinosis, had been analyzed. <...> A comparative analysis of clinical and immunological effi cacy of subcutaneous and oral methods of ASIT by the arithmetic means and medians had been held. <...> There was defi ned a positive clinical eff ect of ASIT and the comparison of it`s degree at the subcutaneous and oral ASIT had been assessed. <...> Доказано, что пероральная форма АСИТ является более предпочтитель32 Оригинальные исследования ной у детей, так как при большей клинической эффективности она обеспечила сопоставимую иммунологическую эффективность, а также лучший комплаенс больного с врачом и более высокий профиль безопасности. <...> Ключевые слова: клиническая эффективность, иммунологическая эффективность, аллерген-специфическая иммунотерапия, средний арифметический показатель, медиана, интерлейкины, дети, поллиноз. _________________________________________________________________________________________________ Pollinosis is an allergic disease caused by hypersensitivity to pollen and manifests itself in the forms of bronchial asthma, rhinitis and rhinoconjunctivitis. <...> Pollinosis is a wide- spread disease among children in Ukraine, which has a steady increasing trend. <...> At present the only etiological treatment of pollinosis is allergen-specifi c immunotherapy (ASIT) by allergen preparations [5, 12, 14]. <...> In modern allergy and immunology it is believed that continuous delivery of allergens in high dilutions with gradual dose increase causes a decrease in population of T-lymphocyte helpers type 2 (Th-2), leading the immunity by the way of allergic infl ammation, and increases T-lymphocytes helpers type 1 (Th-1), which provide a non-allergic anti-infection immunity [6, 9]. <...> However, comparison of clinical and immunological effi cacy of these two ASIT methods in children with pollinosis is an open question that requires a profound study [4, 12, 14]. <...> THE AIM OF STUDY To compare <...>