Оригинальные исследования Sviatenko Т.1 , Voznyak І.2 Danylo Halytsky Lvov National Medical University, Lvov, Ukraine Святенко Т.В.1 , Возняк И.Я.2 Днепропетровск, Украина 2 Украина Immunohistochemical parameters of neoangiogenesis in patients with psoriasis Иммуногистохимические маркеры неоангиогенеза у пациентов с псориазом ______________________ Резюме __________________________________________________________________________ Aim of the study – to examine levels of expression of immunohistochemical markers of vascularization depending on the severity of pathological processes in psoriasis. <...> The study included 80 patients with diagnosis of psoriasis vulgaris (common group). <...> Morphological and immunohistochemical exams where held in all the patients in which primary antibodies to VEGF, CD34 and MMP-9 were used. <...> The obtained results allow us to elucidate the role of angiogenesis in the course and persistence of pathological process. <...> These additional prognostic markers also will help to develop eff ective schemes for patients treatment. <...> Ключевые слова: псориаз, иммуногистохимия, неоангиогенез, пролиферация, VEGF, CD34, ММР-9. _________________________________________________________________________________________________ 1 Днепропетровская государственная академия Министерства здравоохранения Украины, Львовский национальный медицинский университет имени Данила Галицкого, Львов, 1 Dnepropetrovsk Medical Academy of the Ministry of Health of Ukraine, Dnepropetrovsk, Ukraine 2 «Дерматовенерология Косметология» № 1 (01), 2015 9 Immunohistochemical parameters of neoangiogenesis in patients with psoriasis INTRODUCTION Nowadays a marked increase in morbidity of chronic dermatoses in the structure of skin diseases is observed. <...> According to data of diff erent researchers 3.5–5% of population of the world suff ers from psoriasis. <...> In general structure of skin diseases its incidence is 9% and among those hospitalized in dermatological inpatient departments – 35–38%. <...> Besides, more cases of torpid, malignant and resistant to treatment course of dermatosis have become one more negative tendency. <...> At present psoriasis is explained as genetically determined chronic multifactor polysystemic dermatosis taking into consideration the data of scientifi c investigations, characterised by benign hyperproliferation of epidermis, papulosquamous rashes, staging of the course and involvement of locomotive apparatus and internal organs into pathologic process. <...> In dermatology there are many chronic diseases, which are rarely lifethreatening for patients, but chronic and incurable character of some of them (including psoriasis) has a negative impact on quality of patients’ life. <...> Psoriasis infl uences all aspects of a patient <...>