We aim to identify common (syntropic) genes of allergic diseases using the base system of genomic studies in humans. <...> The online database HuGENet was used and common (syntropic) genes of allergic diseases (AD): CD14, SPINK5, FLG, IL-4, IL-10, TNF, TLR4wereidentifi ed. Functional competence of these genes lies mainly in the initiation and regulation of immune response and infl ammation. <...> Examination of 2270 children in the United States found that the presence of asthma relative risk of the second of atopic disease (AD) varies from 1.8 to 4.8, in the presence of allergic rhinitis (AR) – from 2.0 to 12.9 [9, 10]. <...> Bronchial asthma is a chronic disease of multifactorial ethiology, the heredity, according to WHO, is inferior to the importance of the combined effect of habitat and lifestyle 108 ВВЕДЕНИЕ По прогнозам комиссии экспертов Всемирной организации здравоохранения к 2020 г. ожидается не только дальнейший рост числа больных бронхиальной астмой (далее – БА), но и переход этой нозологии в группу наиболее распространенных заболеваний [1, 2]. <...> Бронхиальная астма – хроническое заболевание мультифакторной природы, в развитии которого наследственность, по данным Обзоры. <...> Лекции in development of the disease (smoking, alcohol et al.) [2, 3]. <...> Cases of smoking (90%, active and passive) are recognized as a major factor in the development of chronic inflammatory lung diseases (ChILD) and multifactorial such socially significant diseases like cardiovascular disease (CVD), cancer pathology et al. [4] However, bronchial obstruction develops only in 15–30% of smokers, not all smokers are diagnosed with lung cancer, cardiovascular disease. <...> M.L. von Pfaundler-Zeht (Germany, 1921) proposed the concept of syntropic and dystropic diseases: syntropy is a mutual interaction of the two disease states for joint manifestations, and dystrophy – «mutual repulsion» of the diseases [7]. <...> Syntropy is a nature phenomenon of a combination of two or more pathological conditions (nosology or syndromes) in a human and his immediate family, this phenomenon has a non-random evolutionary-genetic basis [9]. <...> Nonrandomness in a combination of certain forms of a disease (nosology, syndromes), combined by the similarity of pathogenesis, indicates the possibility of common genes of susceptibility involvement to the development of individual components and the formation <...>