Богомольца, Киев, Украина Characteristics of pathogenesis of acute and recurrent oral candidiasis under experimental conditions (part 1) Особенности патогенеза острого и рецидивирующего кандидоза полости рта в условиях эксперимента (часть 1) ______________________ Abstract __________________________________________________________________________ An experimental model of chronic oral candidiasis, which adequately reproduces the recurrence of the disease and can be used to study the major pathogenic mechanisms of the disease and determine the eff ectiveness of antifungal drugs. <...> Under the experimental conditions studied pathological changes that occur at diff erent etaps of infection in the mouth, the digestive system, liver, and spleen of experimental animals. <...> Keywords: experimental model in laboratory animals, oral candidiasis, chronic candidiasis, pathological changes postinfection laboratory markers of immune defi ciency. _________________________________________________________________________________________________ INTRODUCTION Chronic lesions of oral mucosa is one of the topical problems of modern pediatric dentistry and gastroenterology due to its prevalence, severe clinical deployments and risks of recurrency. <...> Traditionally, the most common agent of chronic lesions of oral mucosa are уests of genus Candida. <...> The specifi c weight of candidial lesions of oral mucosa has increased signifi cantly due to the augmentation of a number of severe and atypic clinical forms, which are resistant to traditional therapy, high risk of complications and infection generalization. <...> The pathogenic speciality of сandidiasis 8 ВВЕДЕНИЕ Хронические поражения слизистой оболочки полости рта (СОПР) представляют собой одну из актуальных проблем современной детской стоматологии и гастроэнтерологии вследствие их значительной распространенности, тяжелых клинических проявлений, риска рецидивирования. <...> Традиционно наиболее распространенными возбудителями хронических поражений СОПР у детей являются грибы рода Candida. <...> Удельный вес кандидозных поражений СОПР существенно возрос за счет увеличения количества тяжелых и атипичных клинических форм, резистентных к традиционной терапии, высокого риска возникновения осложнений и генерализации 1 Shupyk National Medical Academy of Post-Graduate Education, Kyiv, Ukraine 2 Оригинальные исследования as a chronic infectious disease is desintegration of anti-infective resistention mechanisms. <...> RESEARCH MATERIALS AND METHODS Characteristics of experimental material and procedure of the experiment The essence of the experimental research lied in: extrapolation <...>