Пирогова, Винница, Украина Role of sex hormones and growth factors in the genesis of development of chronic pain syndrome in women of reproductive age Роль половых гормонов и факторов роста в генезе формирования хронического болевого синдрома у женщин репродуктивного возраста ______________________ Abstract __________________________________________________________________________ The article presents the data on hormonal profile of women with chronic pelvic pain syndrome, which was studied through determination of sex hormones level during the menstrual cycle and concentration of the main growth factors that reflect the angiogenesis activity processes and proliferation within determination of basic etiopathogenetic mechanisms of pain formation in the lower abdomen. <...> Keywords: chronic pelvic pain syndrome, sex hormones, growth factors, etiopathogenesis. ______________________ Резюме __________________________________________________________________________ В статье приведены данные про гормональный профиль женщин с синдромом хронической тазовой боли, изучение которого проводили путем определения уровня гормонов на протяжении менструального цикла, а также концентрации основных факторов роста, которые отображают активность процессов ангиогенеза и пролиферации, в рамках определения основных этиопатогенетических механизмов формирования болевых ощущений в нижних отделах живота. <...> According to the modern ideas of pathological pain genesis in general and pelvic pain in particular the tissue hypoxia plays a leading role in this process, associated with prolonged and flagrant microcirculation disturbance; innervational apparatus disturbance and endocrine homeostasis abnormality, including hormone imbalance that occurs at the tissue level [10]. <...> The role of sex steroids in the formation of pain is confirmed by the fact of reduction or complete disappearance of some pain syndromes which was observed in postmenopausal women [3, 6]. <...> In this regard it should be noted that namely estradiol was a strong anti – inflammatory factor in the chronic pelvic pain syndrome genesis. <...> In addition, chronic pelvic pain syndrome is often accompanied with endocrine disorders such as dishormonal disorders that lead to structural changes of inner sex organs, connected with proliferation of tissue – endometrial hyperplasia, uterine fibroids, etc. [5]. 342 «Reproductive health. <...> Оригинальные исследования Thus, chronic pelvic pain has a multiple factor etiology and pathogenesis, where the main links are <...>