Горбачевского, Тернополь, Украина Flow phenomena of experimentally induced endometreosis in rats during the immunocorrection with a metabolic immune response modifi er 5-amino-1,2,3,4tetrahydrophthalazine-1,4-dione of sodium salt Особенности протекания экспериментальн оиндуцированного эндометриоза у крыс при иммунокоррекции метаболическим иммуномодулятором 5-амино-1,2,3,4тетрагидрофталазин-1,4-дион натриевой соли ______________________ Abstract __________________________________________________________________________ The results of the experimental observation of the metabolic immune response modifi er 5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione of sodium salt impact on endometriosis genitalis externa in 50 scrub rats are refl ected in the article. <...> It is established that immunocorrective therapy held by metabolic immune response modifi er in female rats with endometreosis provides a recovery of a sexual cycle and improves the experimental disease procedure. <...> Среди категории лиц, страдающих синдромом тазовых болей, эндометриоз обнаруживают в 38,8%, а среди женщин с бесплодием – в 50% случаев. <...> Многими авторами доказано, что эндометриоз является только гинекологическим проявлением системной патологии, в основе которой лежит дисрегуляция различных иммунных и гормональных процессов. <...> One of the modern immune response modifi ers is 5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione of sodium salt. <...> The medicine guarantees the antioxidant eff ect and has anti-infl ammatory property, which infl uence positively on the course of the disease. <...> The aim of our work was to examine the impact of the metabolic immune response modifi er 5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione of sodium salt on the peculiarities of estrous cycle and the organic symptoms of endometreosis in rats during the experiment. <...> MATERIALS AND METHODS The experiment on 50 white female rats was carried out. <...> The scheme of the experimental model of endometreosis included autotransplantation of the left uterine horn fragments to the internal surface of the uterus in such a way that the endometrium was turned to the abdominal cavity. <...> The investigated animals were divided into two groups: the main group consisted of 25 scrub female rats with experimentally induced endometriosis, which were given hypo of 5-amino-1,2,3,4-tetrahydronaphthalene-1,4dionesodium salt dosed by 2 mg/kg per day in 1ml in physiological solution during 15 days; the control group included 25 scrub female rats with experimental endometreosis. <...> The animals were given hypo in equivalent amount of physiological solution during 15 days. <...> The medical treatment with the use of proposed immunomodulatory started in 4 <...>