AGRICULTURAL BIOLOGY, 2015, V. 50, ¹ 6, pp. 709-718 ISSN 2412-0324 (English ed. Online) (SEL’SKOKHOZYAISTVENNAYA BIOLOGIYA) ISSN 0131-6397 (Russian ed. Print) ISSN 2313-4836 (Russian ed. Online) Reviews, advances, challenges / doi: 10.15389/agrobiology.2015.6.709rus doi: 10.15389/agrobiology.2015.6.709eng HUMORAL AND CELL IMMUNE MECHANISMS UNDER AFRICAN SWINE FEVER (review) A.D. SEREDA, A.S. KAZAKOVA, A.R. IMATDINOV, D.V. KOLBASOV Russian Academy of Agricultural Sciences, Pokrov, Petushinskii Region, Vladimir Province, 601120 Russia, e-mail sereda-56@mail.ru A b s t r a c t tion in local populations of The evidences for protective immunity against African swine fever are symptomless infec, , spp. <...> In Africa and experimentally produced avirulent strains of African swine fever virus (ASFV), preventing death in pigs inoculated with its virulent homolog. <...> Serum or colostrum from convalescent animals can delay clinical symptoms, decline viremia and increase the survivors’ rate (R.C. Knudsen et al., 1987; D.H. Schlafer et al., 1984; D.V. Onisk et al., 1994). <...> Humoral immune response is most probably due not to ASFV neutralization but the complement-mediated cytolysis (CMC) and antibodymediated cell cytotoxicity (AMCC) (V.V. Makarov, 2013). <...> Cell-mediated defense mechanisms, lyses of infected cells by N-killers and cytotoxic T-lymphocytes (CTL) lead to chronic or symptomless infection (S.G. Norley et al., 1983, 1984). <...> An in vivo depletion of CD8+ T-lymphocytes by monoclonal antibodies was shown to stop protective immunity in pigs pre-immunized with an attenuated ASFV strain under next inoculation with the virulent homolog (C.A.L. Oura et al., 2005). <...> Induction and defector activity of AMCC and CTL depend on the dose and biological features of ASFV strain (A.D. Sereda, 2010). <...> High AMCC since day 3 and activity of cell-mediated mechanisms of immunity on day 6 after the ASFV inoculation provide a rapid decrease of the virus titers in blood, and, consequently, the absence of clinical symptoms (A.D. Sereda et al., 1992). <...> Humoral and celldependent defense mechanisms act synergistically that must be taken into consideration when developing candidate recombinant vaccine <...>