NEVROLOGICHESKIY ZHURNAL, № 3, 2016 DOI 10.18821/1560-9545-2016-21-3-165-167 СLINICAL RESEARCHES AND CASE REPORTS © КОЛЛеКТИВ АВТОРОВ, 2016 УДК 616.832-002-053.2-07 Voytenkov V.B.1 , Skripchenko N.V.1 , Zueva Y.E.2 , Klimkin A.V.1 , Skripchenko E.Y.3 FuNCTioNAL STATE oF MoToR NEuRoNS AND iTS EvALuATioN By TRANSCRANiAL MAGNETiC STiMuLATioN iN CHiLDREN WiTH iNFLAMMAToRy LESioNS oF THE BRAiN 1 Scientific Research Institute of Children’s Infections, 197022, Professora Popova, 9, Saint-Petersburg, Russia; e-mail: vlad203@ inbox.ru; 2 Department of Molecular Biology, faculty of natural Sciences, ariel university, ariel, 44837, Israel; 3 State budget institution of higher professional education Saint-Petersburg State Pediatric Medical university, Ministry of health of the Russian federation, Saint-Petersburg, Russian federation Aim of study was to evaluate functional state of central nervous system motoneurons in patients with inflammatory disseminated small lesions of the brain. <...> Mean age of the group of children with ADEM and MS was 14 years, there were 14 boys & 18 girls. <...> All patients underwent transcranial magnetic stimulation (TMS), single-pulse protocol. <...> Results: TMS showed good tolerability in children with encephalomyelitis and multiple sclerosis. <...> Central motor pathways in patients with relatively small disseminated (multiple sclerosis, ADEM) lesions demonstrated high durability and stable TMS parameters, perhaps due to neuroplasticity. <...> But it have to be noted, that in children in both MS and ADEM groups elevation of MEP threshold was seen significantly more often, which may be interpreted as signs of abnormal lowered functional state of motoneurons. <...> As non-invasive, sensitive and relatively safe method, TMS should be more often implemented into the diagnostic protocols in pediatrics. <...> B., Skripchenko n.v., Zueva y.e., Klimkin a.v., Skripchenko e.y. functional state of motor neurons and its evaluation by transcranial magnetic stimulation in children with inflammatory lesions of the brain. <...> Войтенков В.Б.1 , Скрипченко Н.В.1 ФГбУ Научно-исследовательский институт детских инфекций федерального медико-биологического агентства, 197022, Профессора Попова, 9, Санкт-Петербург, Россия; e-mail:vlad203@inbox.ru; 2 faculty of natural Sciences <...>