УСПЕХИ ГЕРОНТОЛОГИИ • 2015 • Т. 28 • № 2 © I. Srivastava, N. Thukral, Y. Hasija, 2015 УДК 575.113:616-053 I. Srivastava, N. Thukral, Y. Hasija GENETICS OF HUMAN AGE RELATED DISORDERS* Department of Biotechnology, Delhi Technological University, Shahbad Daulatpur, Main Bawana Road, Delhi-110042, India; e-mail: yashahasija@gmail.com Aging is an inevitable biological phenomenon. <...> ARDs are becoming a key social and economic trouble for the world’s elderly population (above 60 years), which is expected to reach 2 billion by 2050. <...> Advancement in understanding of genetic associations, particularly through genome wide association studies (GWAS), has revealed a substantial contribution of genes to human aging and ARDs. <...> Further analysis of the genetic association studies through pathway analysis several genes associated with multiple ARDs have been highlighted such as apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF), cadherin 13 (CDH13), CDK5 regulatory subunit associated protein 1 (CDKAL-1), methylenetetrahydrofolate reductase (MTHFR), disrupted in schizophrenia 1 (DISC1), nitric oxide synthase 3 (NOS3), paraoxonase 1 (PON1), indicating that these genes could play a pivotal role in ARD causation. <...> These genes were found to be signifi cantly enriched in Jak-STAT signalling pathway, asthma and allograft rejection. <...> Further, interleukin-6 (IL-6), insulin (INS), vascular endothelial growth factor A (VEGFA), estrogen receptor1 (ESR1), transforming growth factor, beta 1(TGFB1) and calmodulin 1 (CALM1) were found to be highly interconnected in network analysis. <...> We believe that extensive research on the presence of common genetic variants among various ARDs may facilitate scientists to understand the biology behind ARDs causation. <...> Key words: Age related disorders (ARDs), Genetic variation, Single nucleotide polymorphism (SNP), Genome-wide Association Studies (GWAS), Network analysis, signalling pathways Low probabilities of disease, high cognitive and physical function capacity, and active engagement in life are believed to be the secrets of healthy aging. <...> By 2050 the world`s elderly population (above 60 years) is expected to reach 2 billion [31]. <...> Many <...>