DISCRIMINATIVE VALUE OF RESTING- STATE EEG BIOMARKER BETWEEN FRAGILE X SYNDROME, AUTISM SPECTRUM DISORDERS, AND TYPICAL DEVELOPMENT (726,00 руб.)

Первый автор	Gorbachevskaya
Авторы	Mitrofanov A., Dallada N., Sorokin A.
Страниц	20

ID	950520
Аннотация	The aim of this study was to explore the discriminatory potential of resting- state EEG in distinguishing between children and adolescents aged 3 to 19 years with Fragile X syndrome ( FXS) , autism spectrum disorders ( ASD) , and typical development ( TD) , using spectral EEG analysis. Resting- state EEG was recorded from 16 standard 10–20% electrode locations in 69 participants with FXS, 120 with ASD, and 700 typically developing participants. A linear discriminant analysis was conducted using the Brainsys software package for EEG analysis and topographic mapping. Significant spectral differences were observed between the ASD and FXS groups, including lower theta- band power in ASD compared to FXS, and higher power in the alpha and beta- 1 frequency bands. Both clinical groups also showed distinct spectral characteristics compared to the TD group. Notably, resting- state EEG demonstrated a strong predictive ability in distinguishing FXS from ASD, with a sensitivity of 94% and a specificity of 85% , based on three key predictors. FXS participants showed a distinct EEG profile characterized by increased theta and beta- 2 power and reduced alpha power. The linear discriminant analysis reliably classified subjects into ASD, FXS, and TD groups with high specificity and sensitivity. These findings support the validity of EEG as a biological biomarker for both FXS and ASD. The identified spectral patterns may contribute to clinical evaluation protocols and serve as valuable tools in intervention studies

DISCRIMINATIVE VALUE OF RESTING- STATE EEG BIOMARKER BETWEEN FRAGILE X SYNDROME, AUTISM SPECTRUM DISORDERS, AND TYPICAL DEVELOPMENT / N. Gorbachevskaya [и др.] // Журнал высшей нервной деятельности им. И.П. Павлова .— 2026 .— №1 .— С. 23-42 .— URL: https://rucont.ru/efd/950520 (дата обращения: 11.04.2026)