Assessment of Genetic Deterministic Processes of Drug Metabolism (190,00 руб.)

Стр.2

Стр.3

UDC 615:577.1 Published by the decision of the Editorial Review Board of the Kazan National Research Technological University Reviewers: PhD., Professor G. Budnikov PhD., Professor S. Egorova Garmonov S. Assessment of Genetic Deterministic Processes of Drug Metabolism : monograph / S. Garmonov, L. Nugbienyo; The Ministry of Science and Higher Education of the Russian Federation, Kazan National Research Technological University. – Kazan : KNRTU Press, 2022. – 120 p. ISBN 978-5-7882-3223-2 This monograph contains review of the current state and prospects of development of analytical methods for the study of genetic deterministic processes of drug metabolism in the human body. It also discusses the role of analytical methods in determining the activity of enzyme systems that control the processes of biotransformation of xenobiotics and endogenous compounds in the body. The monograph also demonstrates the application of chemical and physico-chemical methods of analysis for direct and indirect determination of metabolic and exogenous markers of biotransformation. It is intended to serve as a teaching and learning material for postgraduate and PhD students of Russian universities, studying Pharmacy. Prepared at the Department of Analytical Chemistry, Certification and Quality Management. UDC 615:577.1 ISBN 978-5-7882-3223-2 © S. Garmonov, L. Nugbienyo, 2022 © Kazan National Research Technological University, 2022 2

Стр.2

CONTENTS List of abbreviations ...................................................................................... 4 FOREWORD ................................................................................................ 5 INTRODUCTION ......................................................................................... 7 Chapter 1. PHARMACOKINETICS AND METABOLISM OF DRUGS ................................................................................................. 12 Chapter 2. OXIDATIVE METABOLISM AND METHODS OF DETERMINATION OF MICROSOMAL OXIDASE ACTIVITY ........... 24 Chapter 3. PHASE II REACTIONS OF BIOTRANSFORMATION. ACETYLATION ......................................................................................... 35 Chapter 4. METABOLISM OF MESALAZINE AND ITS PRODRUGS ............................................................................................... 48 Chapter 5. METABOLISM OF SULFONAMIDES ................................... 55 Chapter 6. PHARMACOKINETICS AND METABOLISM OF PROCAINAMIDE ...................................................................................... 67 Chapter 7. QUANTITATIVE DETERMINATION OF DRUGS IN BIOLOGICAL FLUIDS ........................................................................ 75 Chapter 8. RELATIONSHIP OF ACETYLATION RATE WITH VARIOUS DISEASES .................................................................... 82 CONCLUSION ........................................................................................... 89 References ................................................................................................... 90 3

Стр.3