к л и н и ч е с к о е н а б люд е н и е The severe form of ovarian hyperstimulation syndrome, complicated by an abruption of an ovary and a massive intraabdominal bleeding A.I.Davydov, V.M.Pashkov I.M.Sechenov First Moscow State Medical University, Moscow, Russian Federation Clinical case of the severe form of ovarian hyperstimulation syndrome, at which the maximum sizes of ovaries have reached 25 and 40 sm, that has led to a complete separation of an ovary and a massive intraabdominal bleeding, is presented. <...> For maintenance of a hemostasis during operation the plasma surgery – system "PlasmaJet" is used. <...> Key words: severe ovarian hyperstimulation syndrome, intraabdominal bleeding, plasma surgery, PlasmaJet surgery Тяжелая форма синдрома гиперстимулированных яичников, осложненная отрывом яичника и массивным внутрибрюшным кровотечением А. <...> Сеченова, Москва, Российская Федерация Представлено клиническое наблюдение тяжелой формы синдрома гиперстимулированных яичников, при которой максимальные размеры яичников достигли 25 и 40 см, что привело к полному разрыву яичника и массивному внутрибрюшному кровотечению. <...> At the same time, even "soft" IO can lead to development of serious systemic complication – an ovarian hyperstimulation syndrome (OHS). <...> OHS is an iatrogenic complication, which develops as a result of activation of production of vasoactive mediators by ovaries against the stimulation of superovulation. <...> OHS is characterised by increase of permeability of a wall of capillaries, accompanied by transition of intravascular liquid in the extravasated space, its accumulation in the third space and haemoconcentration. <...> As a rule, OHS forms in response to injection of Gonadotropinums, however in some cases the syndrome can manifest itself after IO with Clomiphenum, and also at the beginning of pregnancy in a Contacts: Alexander I. Davydov, MD, DSc, Professor, Department of obstetrics, gynecology and perinatology of I.M.Sechenov First Moscow State Medical University Address: 119991, street Trubetsky, 8, p. 2, Moscow, Russia Telephone: (499) 782-3341 Статья поступила 18.06.2014 г., принята к печати 27.10.2014 г. 82 spontaneous cycle. <...> Today the syndrome is regarded as the systemic aseptic inflammatory <...>