О р и г и н а л ь н а я с т а т ь я DOI: 10.20953/1729-9225-2017-1-35-40 Инфекционные болезни, 2017, т. 15, №1, с. 35–40 Infectious diseases, 2017, volume 15, No 1, p. 35–40 Anti-phage аntibody response in phage therapy against healthcare-associated infections (HAIs) S.S.Bochkareva1 , A.V.Aleshkin1 I.A.Kiseleva1 , E.R.Zul’karneev1 , O.N.Ershova2 , E.O.Rubal’skiy1 , L.I.Novikova1 , M.V.Zeigarnik4 , A.V.Karaulov3 , 1G.N.Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Moscow, Russian Federation; 2N.N.Burdenko Neurosurgery Research Institute, Moscow, Russian Federation; 3Sechenov State Medical University, Moscow, Russian Federation; 4N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation The objective. <...> Forty-two patients on prolonged mechanical ventilation in a neurological ICU were administered bacteriophage cocktail per os, including six patients repeatedly – from 3 to 5 courses. <...> Repeated courses of phage therapy with the same strains did not lead to a substantial eradication of pathogens. <...> Anti-phage immunity after a single application of bacteriophage cocktail with a certain composition of strains was detected with ELISA by the presence of titer of specific IgG antibodies in the range of 1/16-1/4096 (no antibodies were present in patients who did not take the cocktail). <...> The effectiveness of a bacteriophage may be reduced if a patient is given a repeated treatment due to the formation of anti-phage antibodies. <...> Key words: bacteriophages, HAIs, antibiotic resistance, humoral immune response, anti-phage antibodies For citation: Bochkareva S.S., Aleshkin A.V., Ershova O.N., Novikova L.I., Karaulov A.V., Kiseleva I.A., Zul’karneev E.R., Rubal’skiy E.O., Zeigarnik M.V. Anti-phage аntibody response in phage therapy against healthcare-associated infections (HAIs). <...> Бурденко, Москва, Российская Федерация; 3Первый Московский государственный медицинский университет им. <...> Сеченова, Москва, Российская Федерация; 4 Российский национальный исследовательский медицинский университет им. <...> Антифаговый иммунитет после однократного применения коктейля бактериофагов конкретного штаммового состава детектировали с помощью Для корреспонденции: Svetlana S.Bochkareva, PhD <...>