Медицинская иммунология 2016, Т. 18, № 6, стр. 521-536 © 2016, СПб РО РААКИ Обзоры Reviews РОЛЬ РАЗЛИЧНЫХ СУБПОПУЛЯЦИЙ CD4+ Medical Immunology (Russia)/ Meditsinskaya Immunologiya 2016, Vol. 18, © 2016, SPb RAACI Т-ЛИМФОЦИТОВ ПРИ БЕРЕМЕННОСТИ Соколов Д. <...> В обзоре обсуждается роль субпопуляций Th1-, Th17-, Th2- и Treg-лимфоцитов в формировании плаценты и иммунорегуляции беременности, а также их взаимодействие с клетками децидуальной оболочки и трофобласта. <...> Ключевые слова: беременность, плацента, лимфоциты, трофобласт, децидуальная оболочка THE ROLE OF THE DIFFERENT SUBPOPULATIONS OF CD4+ T LYMPHOCYTES DURING PREGNANCY Sokolov D.I., Stepanova O.I., Selkov S.I. D.O. Ott Research Institute of Obstetrics, Ginecology and Reproductology, St. Petersburg, Russian Federation Abstract. <...> An important role in the formation of immunological tolerance during pregnancy play T lymphocytes. <...> In the present review discusses the characteristics of T lymphocytes, decidua and placenta, especially their migration and functional activity during pregnancy. <...> The review discusses the role of the subpopulations of Th1, Th17, Th2 and Treg lymphocytes in the formation of the placenta and the immune regulation of pregnancy, as well as their interaction with the cells of the decidua and trophoblast. <...> Keywords: pregnancy, placenta, lymphocytes, trophoblast, decidua Introduction Pregnancy is an example of the unique cooperation between the maternal and the semi-allogenic fetus organism. <...> During pregnancy an adaptation to fetus development and securing of maternal organism, first of all her immune system, occurs. <...> An important aspect of maternal immune response transformation is a formation of immune tolerance, in development of which decidua macrophages [3], T lymphocytes, Адрес для переписки: Соколов Дмитрий Игоревич ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им Д. <...> Сельков «Роль различных субпопуляций CD4+ Т-лимфоцитов при беременности» // Медицинская иммунология, 2016. <...> The most distinct changes of immune system population cell composition at pregnancy is observed in the zone of the uteroplacental bed, where endometrium Address for correspondence: Sokolov Dmitry I. D.O. Ott Research Institute of Obstetrics, Ginecology and Reproductology 199034, Russian Federation, St. Petersburg, Mendeleevskaya line, 3. <...> Medical Immunology (Russia)/Meditsinskaya Immunologiya <...>