ИННОВАЦИОННЫЕ ТЕХНОЛОГИИ В ПЕДИАТРИИ И ДЕТСКОЙ ХИРУРГИИ Silva M. L. M.4 , de Jesus Marques-Salles T.1 Pediatric Oncohematology Center, Hospital Oswaldo Cruz/ Pos Graduation Course of the Faculty of Medical 1 Sciences, University of Pernambuco, Recife/PE, Brazil; 2 Biologic Sciences Institute, Pernambuco University, Recife/PE, Brazil; 3 Jena, Germany; 4 Jena University Hospital, Institute of Human Genetics, Cytogenetic Department, National Center for Bone Marrow Transplant (CEMO-INCA), National Cancer Institute, Rio de Janeiro/RJ, Brazil Fanconi Anemia (FA) is an inherited disorder with congenital and developmental abnormalities, bone marrow failure and an extreme risk to develop myelodysplastic syndrome or acute myeloid leukemia. <...> Cytogenetic surveillance of bone marrow is an important part of the clinical management of FA as cytogenetic aberrations can help to estimate the moment of malignant transfomation. <...> Here, we characterized bone marrow features and implications of chromosomal aberrations in four cases of FA. <...> The molecular karyotyping revealed different acquired abnormalities in three of the four cases, e.g. a high complex and rare karyotype. <...> These features showed that FA provokes serious chromosomes abnormalities which in most cases evolve to hematological malignances with fatal outcome. <...> Due to the appearance of rare and complex chromosomal abnormalities, molecular cytogenetics studies are important to determine the real significance of chromosomal aberrations in malignancies derived from FA. <...> ALPHA-FETOPROTEIN AND ITS VALUE FOR PREDICTING PREGNANCY OUTCOMES — A RE-EVALUATION Darouich A. A.1 Kiehntopf M.3 , Liehr T.1 , Weise A.1 , Schreyer I.1,4 1Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany; 2 Germany; 3 Jena University Hospital, Friedrich Schiller University, Placenta-Labor, Department of Obstetrics, Jena, Jena University Hospital, Friedrich Schiller University, Institute of Clinical Chemistry and Laboratory Diagnostics, Jena, Germany; 4 Jena University Hospital, Zentrum fьr ambulante Medizin, Jena, Germany A retrospective study based on 3,119 singleton and 56 twin pregnancies is presented. <...> The standard levels of amnion fluid <...>