Врачебная практика Iskrov I.1 , Stoma I.2 , Lendina I.1 , Smolnikova V.1 Belarusian State Medical University, Minsk, Belarus Искров И.А.1 1 Clinical Hospital № 9, Minsk, Belarus 2 , Стома И.О.2 , Лендина И.Ю.1 , Смольникова В.В.1 1 9-я городская клиническая больница, Минск, Беларусь 2 Белорусский государственный медицинский университет, Минск, Беларусь Acute lymphoblastic leukemia: a report of two cases in adults in Belarus Острый лимфобластный лейкоз из NK-клеток: описание двух клинических случаев у взрослых пациентов в Беларуси ______________________ Abstract __________________________________________________________________________ Natural killer cell neoplasms are very rare in Europe. <...> Being an aggressive malignancy with poor prognosis, its’ clinical course and treatment in patients from European region have not been widely discussed. <...> We present two cases of acute lymphoblastic leukemia in Belarus, confirmed by immunophenotyping. <...> Malignant cells in case of blastic natural killer cell lymphoma/leukemia (BNKL) have blastic characteristics with appearance of CD3–, CD4–, CD7–, CD8–, CD16–, CD56+ and HLA-DR+ immunophenotypes [2]. <...> We present cases of BNKL occurring in Caucasian male and female in Belarus and describe our experience with peg-L-asparaginase and HyperCVAD chemotherapy regimens. «Гематология. <...> Восточная Европа», 2016, том 2, № 3 397 Acute lymphoblastic leukemia: a report of two cases in adults in Belarus CASE REPORTS Case № 1 A 37-year-old man of Caucasian race was admitted to Minsk city clinical hospital № 9 in Belarus in October of 2015. <...> Sternal puncture was immediately performed, the study of myelogram showed 72.5% of lymphoid cells, 1.5% of promyelocytes, 4% of myelocytes, 4.5% of metamyelocytes, 3% of band neutrophils, 4.5% of segmented neutrophils, 2.5% of monocytes, 5.5% of lymphocytes, red cells sum of 2%, single megacaryocytes. <...> Cytogenetics/FISH of bone marrow cells showed, that 50% of cells have unsTable genomic characteristics with hypo- and hyperdiploidy, no structural chromosome abnormalities found. <...> Cytochemical analysis showed evidence for blastic (lymphoid) cells in bone marrow cells. <...> Numerous quantitative and qualitative PCR analyses of blood did not show any viral load of EBV <...>