UDC 547.814.1 SYNTHESIS OF 3-ACETYL-6-IODO-COUMARIN AND IT’S DERIVATIVES Nguyen Tien Cong, Tran Thi Duong, Nguyen Anh Tien Ho Chi Minh City University of Pedagogy, Viet Nam Поступила в редакцию 19.08.2013 г. <...> Abstract. iodination of the 2-hydroxybenzaldehyde formed 2-hydroxy-5-iodobenzadehyde (2). cyclization of (2) with ethyl acetoacetate gave 3-acetyl-6-iodocoumarin (3). 3-(Bromoacetyl)-6iodocoumarin (4), the product formed when bromination of (3) was transformed into five derivatives containing thiazole ring (6a-e). the structures of the compounds were identified by ir, 1H-nMr and HrMS spectral data. <...> Keywords. 3-acetyl-6-iodocoumarin, 3-(bromoacetyl)-6-iodocoumarin, 3-(2-aminothiazol-4-yl)-6iodocoumarin, 3-[2-(2-arylidenhydrazinyl]thiazol-4-yl]-6-iodocoumarin coumarin derivatives have been focused recently due to potential activities exhibited by them. <...> Modifications on the 3-position of coumarin nucleus have resulted in a large number of compounds having diverse pharmacological activities [1]. thiazole displayed broad range of biological activities as as antitumor, antimicrobial, antifungal, antiinflammatory, anticonvulsant activity [2]. therefore, many 3-substituted coumarins’ derivatives bearing thiazole heterocycle were synthesized with hope of increasing their valuable pharmacological activities [3-10]. <...> EXPERIMENT Melting points were determined in open capillaries and the values are uncorrected. ir spectra of all synthesized compounds were recorded on KBr disks using a Shimadzu Ftir 8400S spectrometer. 1 H-nMr spectra were recorded on a Bruker avance spectrometer (500 MHz) using DMSo-d6 as solvent and tMS (0.00 ppm) as an internal standard. <...> Using a magnetic stir bar, stir until dissolved. add 22.24g © nguyen tien cong, tran thi Duong, nguyen anh tien, 2014 38 (0.134 mol) potassium iodide, and continue to stir. after the potassium iodide has dissolved into solution, put the round bottom flask on an ice/water bath, positioned over the magnetic stirrer so that the solution is still stirring. carefully add 90 ml of the sodium hypochlorite solution dropwise to the round bottomed flask over a period of 120 minutes. <...> During this time, add ice to the ice bath as necessary to maintain a mixture with enough water that the surface area of the round bottomed flask <...>