Нефрология Jan H.M. Blom¹, Hein van Poppel² Prijck6 , Richard Sylvester6 St. Franciscus Gasthuis, Rotterdam, The Netherlands¹, University Hospital Gasthuisberg, Leuven, Belgium², Hopital Edouard Herriot, Lyon, France³, Hospices Civil de Strasbourg, Strasbourg, France4 Erasmus Medical Center, Rotterdam, The Netherlands5 , , EORTC Headquarters, Brussels, Belgium6 Radical Nephrectomy with and without Lymph-Node Dissection: Final Results of European Organization for Research and Treatment of Cancer (EORTC) Randomized Phase 3 Trial 30881 The article was published in journal European Urology, 2009, 55, 28-34. <...> Until now the therapeutic value of lymphadenectomy for renal-cell carcinoma has remained controversial. <...> Several studies attempting to solve this controversy have been published, but none of them were set up as prospective randomized trials. <...> In 1988, the European Organization for Research and Treatment of Cancer (EORTC) Genitourinary Group started a randomized phase 3 trial comparing radical nephrectomy with a complete lymphadenectomy to radical nephrectomy alone. <...> After the renal-cell carcinoma was judged to be N0M0 and resectable, patients were randomly selected prior to surgery to undergo either a radical nephrectomy with a complete lymph-node dissection or to undergo a radical nephrectomy alone. <...> All patients were postoperatively evaluated for time-to-progression, overall survival, and progression-free survival. <...> Time-to-event curves were estimated based on the Kaplan-Meier method and compared using a two-sided log-rank test. <...> The complication rate did not diff er signifi cantly between the two groups. <...> Complete lymph-node dissections in 346 patients revealed an absence of lymph-node metastases in 332 patients. <...> The study revealed no signifi cant diff erences in overall survival, time to progression of disease, or progression-free survival between the two study groups. <...> This study shows that, after proper preoperative staging, the incidence of unsuspected lymphnode metastases is low (4.0%) and that, notwithstanding a possible relationship to this low incidence rate, no survival advantage of a complete lymph-node dissection in conjunction with a radical nephrectomy could be demonstrated. <...> Renal cell cancer, Radical nephrectomy, Lymph-node dissection, Lymph-node metastases, Survival. «Рецепт» № 3 (71), 2010 , Jean M. Marechal³ , Didier Jacqmin4 , Fritz H. Schroder5 , Linda de 125 Radical Nephrectomy with and without Lymph-Node Dissection <...>