Богомольца, Киев, Украина Дефекты в гене филаггрина и риск развития фенотипов, вовлеченных в атопический марш Filaggrin gene defects and risk of development of the phenotypes involved in the atopic march in children ______________________ Resume __________________________________________________________________________ The specifi c pathways connecting epidermal barrier disruption to allergen sensibilization become more and more studied. <...> Atopic dermatitis seems to be a causal risk factor for asthma in the context of fi laggrin gene defects. <...> Although it has been proposed that FLG gene mutations and/or fi laggrin defi ciency may be an evolutionary adaptive advantage in Western civilization. <...> Также предположено, что генные мутации FLG и/или дефицит филаггрина может быть эволюционным адаптивным механизмом для Западной цивилизации. <...> Heritability, the proportion of phenotypic variances that caused by genetic eff ects, varies from study to study in asthma. <...> The genetic factor may account for 40% to 60% of variance in allergen specifi c IgE level, 30% in log eosinophil count and 30% to 60% in positive skin test to dust mite in etiology. <...> In past decades, great eff orts have been exerted in unraveling the genetic basis of asthma and allergic «Педиатрия. <...> Similar to other complex diseases, asthma and allergic diseases are phenotypically heterogeneous and characterized by diverse clinical aspects, varied susceptibility to stimuli and numerous intermediate phenotypic markers for physiological and histopathological changes. <...> Various asthma and atopy related phenotypes have been used in published literatures including various disease statuses such as asthma, atopy, atopic dermatitis, hay fever, asthma severity and intermediate or associated phenotypes such as allergic sensitization, bronchial hyper responsiveness, FEV1, IgE level, eNO and eosinophil counts [1]. <...> Susceptible genes for asthma may be divided into four main groups based on their major functions: Barrier layer and defense; Antigen recognition and presentation; Immunoregulation and Th2 diff erentiation; and Eff ecter targets. <...> Over the last decade, there has been a shift in our thinking, with the epithelium now recognized as a critical player in the development of allergic sensitization [2]. <...> In particular, compelling data from human and mouse studies <...>