Hambardzumyan S.V., Yerevan State Medical University after M. Heratsi, Yerevan, Armenia The role of amyloidal angiopathias in pathogenesis of acute myocardial ischemia at familial mediterranean fever УДК 616.1-056.7-091 Поступила в редакцию 25.05.2012 г. <...> Clinical-morphological analysis of 105 autopsy cases with diagnosis of FMF was done. <...> Cardiac amyloidosis in FMF manifested with massive amyloid depositions in myocardium stroma leads to heart failure and death of patients. <...> Macroscopically cardiomegaly, and microscopically amyloid in the myocardium stroma and vascular walls in such cases was observe. <...> The large amyloid masses of the myocardium stroma according to clinical-instrumental data sometimes as a myocardial infarction were manifested. <...> The zone of infarction macro- and microscopically was not found in autopsy material in such cases and as a “pseudoinfarction” was evaluated. <...> Cardiac failure develops before other organ insuffi ciency. <...> In cases with clinically silent cardiac lesions connected with FMF, moderately expressed cardiomegaly observes, or without any manifestations was in autopsy material. <...> Myocardium ischemia develops in background of cardiac lesions in FMF, in which amyloidal angiopathias and coronary vasculitis are the main predisposing pathogenic factors. <...> Atherosclerotic changes of the vessels were complicated with vascular amyloid depositions. <...> Atherosclerotic changes of the myocardium arteries in background of amyloidal angiopathias more often occurs. <...> Amyloidal angiopathias of the heart at FMF, wich develops in background of cardiopathic amyloidosis, together with atherosclerosis leads to myocardium infarction and death. <...> Key words: Familial Mediterranean fever, cardiopathic amyloidosis, myocardial ischemic infarction, morphology. <...> Renal involvement is known as the main complication in FMF, mostly presents with nephrotic syndrome and chronic renal failure [3, 5]. <...> Оригинальные исследования tively rare complications in FMF, often without clinical manifestations, or manifested after renal transplantation [4, 7]. <...> MATERIAL AND METHODS We have investigated morphologically the autopsy material from 105 patients aged 15–65 years and dead from complications of FMF without renal transplantation. <...> Clinically manifested cardiac lesions without morphological manifestations in 23 cases (21.9%) were discovered as a heart defect and accompanied with FMF ischemic heart disease. <...> Cardiac amyloidosis in investigated cases clinically as an acute or chronic ischemic heart disease, cardiomyopathy <...>