PossiBle role oF trAnsthyretin in the BioloGiCAl MeChAnisM oF the reGUlAtory PePtiDe neUroProteCtion Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation the peptide preparation semax has been effectively used for therapy of ischemic stroke. however, the mechanisms of its action are insufficiently understood and actively studied. the full-genome analysis of the transcriptome implemented in our recent work demonstrated that under conditions of focal ischemia of rat brain the semax modified the profile of the transcription activity of many genes. in this case, the difference in the transcription levels of the gene encoding the protein transthyretin (ttr) expression in rats under the pathological conditions of ischemia and in the presence of semax was very high. high similarity between the effects of ttr and coupled molecular systems with the semax effects in ischemic stroke allowed us to suggest that the neuroprotection mechanisms of semax (and, possibly, of other neuroprotection mechanisms of semax) could be mediated by ttr. in this review, we discussed the role of ttr in Cns and its possible role in the neuroprotection mechanism of semax. <...> Key words: regulatory peptides, Semax, transthyretin (prealbumin), cerebral ischemia, neuroprotection For citation: Vyunova t.V., Medvedeva e.V., Andreeva l.A., Dergunova l.V., limborska s.A., Myasoedov n.F. <...> Possible role of transthyretin in the Biological Mechanism of the regulatory Peptide neuroprotection. <...> 1 , ХАРАКТЕРИСТИКА ГРИбНЫХ ШТАММОВ — ПРОДУЦЕНТОВ ТЕРМОСТАбИЛьНЫХ КСИЛОГЛюКАНАз Из ВСЕРОССИЙСКОЙ КОЛЛЕКЦИИ ПРОМЫШЛЕННЫХ МИКРООРГАНИзМОВ 1 2 Технический университет г. Мюнхена, Институт микробиологии, 85345, Фрайзинг, Германия; 3 Институт молекулярной генетики РАН, 123182, Москва, Россия Проведен скрининг ксилоглюканазной активности <...>