Tavlueva E., Barbarash O., Usoltseva E. Research Institute for Complex Issues of Cardiovascular Diseases of the Russian Academy of Sciences, Kemerovo, Russia Тавлуева Е., Барбараш О., Усольцева Е. <...> Научно-исследовательский институт комплексных вопросов развития сердечно-сосудистых заболеваний Российской академии наук, Кемерово, Россия Association between brain natriuretic peptide levels in women and men with myocardial infarction and one-year outcome Взаимосвязь между уровнями мозгового натрийуретического пептида у женщин и мужчин, перенесших инфаркт миокарда, и однолетним исходом заболевания ______________________ Abstract __________________________________________________________________________ Objective. <...> To compare brain natriuretic peptide (NT-proBNP) levels in women and men with ST elevation myocardial infarction (STEMI) in relation to one-year outcome. <...> NT-proBNP serum concentrations were measured at days 10–14 by means of ELISA using BIOMEDICA GRUPPE test system. <...> The rates of recurrent myocardial infarction, unstable angina, arrhythmias, decompensated congestive heart failure, cerebrovascular accidents (CVA) and death were assessed after 12 months of follow-up. <...> When assessing one-year outcome, it was found that vascular events were signifi cantly more frequent in women [24 (47.05%) cases as compared to 47 (33.09%) in men, р=0.001]. <...> No similar diff erences were found in women. <...> There are no signifi cant diff erences in NT-proBNР concentrations in men and women with STEMI. <...> Older men (≥65) with unfavorable outcome have the highest plasma NTproBNP levels 12 months after STEMI. <...> Оценить взаимосвязь уровня мозгового натрийуретического пептида (NT-proBNP) у женщин и мужчин с инфарктом миокарда на фоне подъема сегмента ST (STEMI) и исходом заболевания в течение одного года. <...> These peptides perform a number of important functions; particularly, they regulate myocyte growth, inhibit fi broblast proliferation, have anti-ischemic cytoprotective eff ect, aff ect coronary endothelium and cardiomyocyte contractility. <...> In acute ischemia, brain natriuretic peptide (BNP) is rapidly released by the ventricular myocardium to urgently regulate the myocardial function in the inotropic state and coronary vascular tone. <...> Synthesized as an inactive molecule in response to increased ventricular wall stress <...>