УДК 618.145–006.03–02:575.113.2 Malanchuk L., Martinyuk V. I. Horbachevsky Ternopil State Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine Маланчук Л. <...> Горбачевского Министерства здравоохранения Украины, Тернополь, Украина The correlation of immunodependent mechanisms and glutathione S-тransferase producing gene deletions in endometriosis Взаимосвязь иммунозависимых механизмов с делецией генов глутатион-S-трансферазы в развитии генитального эндометриоза ______________________ Abstract __________________________________________________________________________ The article is devoted to the actual problem today – the study of the relationship immunodependent mechanisms of gene deletion glutathione S-transferases in a brilliant development of endometriosis. <...> Gene network of this disease is rather complicated and diverse. <...> It includes various genes metabolism (detoxifi cation), genes that are responsible for immune status of genes and cell-cell interactions. <...> Polymorphism of genes of detoxifi cation often infl uences the functional activity of the molecular structure of DNA. <...> In recent years in world literature there is more data to the pathological processes in the human body is due to immune regulation and characterized by a certain imbalance of pro- or anti-infl ammatory cytokines, which contribute to the occurrence of endometriosis and can infl uence the eff ectiveness of treatment. <...> В статье представлены результаты исследования роли делеционных вариантов генов GSTT1 и GSTM1. <...> It is known that the genesis of genital endometriosis (GE) is related to genes responsible for metabolism, characterized by a highly variable DNA structure. <...> Currently the role of the humeral response in regulating immune reactions is well studied [6–8]. <...> Восточная Европа» № 6 (42) 2015 63 Взаимосвязь иммунозависимых механизмов с делецией генов глутатион-S-трансферазы в развитии генитального эндометриоза METHODS The clinical portion was carried out at the Ternopil perinatal center “Mother and Child”. <...> Laboratory diagnostics in the in interdepartmental scientifi c – clinical laboratory SHEI “I. Horbachevsky Ternopil State Medical University of the Ministry of Health of Ukraine” 40 female patients were admitted with GE, ages ranging between 27 and 45 years. <...> The control group consisted of 20 women determined to be without GE after inspection, as well as without any signs of ovary or menstrual dysfunction. <...> All patients granted informed consent for the collection <...>