Role of Environmental and Genetic Factors in the Development of Hemodynamically Significant Congenital Heart Diseases in a Coal Mining Region (300,00 руб.)

Химия в интересах устойчивого развития 24 (2016) 561–568 UDC 575.167 DOI: 10.15372/KhUR20160417 Role of Environmental and Genetic Factors in the Development of Hemodynamically Significant Congenital Heart Diseases in a Coal Mining Region A. V. SHABALDIN1, S. A. SHMULEVICH2, E. S. ANIKEEVA1, A. V. TSEPOKINA1, V. P. POTAPOV3 and E. L. SCHASTLIVTSEV3 1Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia E-mail: weit2007@yandex.ru 2Kemerovo Cardiology Dispensary, Kemerovo, Russia 3Kemerovo Branch of the Institute of Computational Technologies, Siberian Branch, Russian Academy of Sciences, Kemerovo, Russia Abstract A cross-sectional retrospective passive epidemiological study for pediatric population aged 0–17 was performed using stratified random sampling. <...> Children with hemodynamically significant congenital heart disease (CHD) in the period from 2005 to 2012 were identified using the official statistical database of the Department of Public Health in the Kemerovo region. <...> In addition, a prospective study of 188 children with hemodynamically significant CHD admitted to the Department of Pediatric Cardiology at the Kemerovo Cardiology Dispensary was conducted. <...> The average incidence of hemodynamically significant CHD in the large cities with 137Cs contaminated soil surface layers was significantly higher compared to that rate in the cities of the Kemerovo region, where the surface layers of intact soils are not contaminated with radioactive cesium (Tgr (av.) = +13.24 %; 95 % CI [9.25, 17.23] vs. Tgr (av.) = +5.31 %; 95 % CI [1.54, 9.07]; p < 0.05). <...> Positive associations have been found between the risk of CHD in the next generation and the HLADRB1*11 and HLA-DRB1*03 allele in the female, the HLA-DRB1*07 allele in the male and a combination of HLA-DRB1*11 in the female and HLA-DRB1*01 in the male. <...> Key words: congenital heart diseases, radioactive cesium 137Cs, HLA-DRB* 561 INTRODUCTION The number of children with congenital heart disease (CHD) is increasing in the Russian Federation, as well as throughout the world [1]. <...> The rapid rise in CHD burden is caused by negative environmental factors that affect the development of a fetus [3]. <...> On the other hand, genetic variability to teratogenic response may explain the differentiated formation of fetal CHD in a number of pregnant women living in the same area <...>