Biology 1 (2016 9) 75-87 ~ ~ ~ УДК 615 462, 547-32 Production of Resorbable Microparticles Loaded with a Cytostatic Drug Using the Spray-Drying Method and Investigation of Their Properties Anastasiya V. <...> Shershneva Institute of Biophysics of SB RAS 50/50 Akademgorodok, Krasnoyarsk, 660036, Russia Received 18.12.2015, received in revised form 014.01.2016, accepted 21.02.2016 Microparticles of resorbable poly-3-hydroxybutyrate loaded with a cytostatic drug (5-fl uorouracil) were prepared by using the spray-drying method. <...> The increase in the level of drug loading from 1 to 10 % of the polymer mass did not signifi cantly effect the average diameter of microparticles (2.4 – 2.6 μm) but increased their ξ-potential (from 106 to 86 mV). <...> Encapsulation effi ciency of 5-fl uorouracil increased with the increase in the level of drug loading. <...> Investigation of the in vitro drug release behavior showed that the total drug release from the microparticles into the medium increased with the growth of mass concentration of the drug (55, 63 and 75 % of the initial drug content and 1, 5 and 10 % of the polymer mass, respectively). <...> The cytotoxic effect of encapsulated 5-fl uorouracil was proved in the HeLa tumor cell culture. <...> All rights reserved * Corresponding author E-mail address: goreva_a@mail.ru # 75 # Anastasiya V. <...> Production of Resorbable Microparticles Loaded with a Cytostatic… <...> Получение резорбируемых микрочастиц, содержащих цитостатический препарат, методом распылительного высушивания и исследование их свойств А.В. Муруева, А.М. Шершнева Институт биофизики СО РАН Россия, 660036, Красноярск, Академгородок, 50 С применением метода распылительного высушивания получены микрочастицы из резорбируемого поли-3-гидроксибутирата П(3ГБ), содержащие противоопухолевый препарат 5-фторурацил. <...> Показано, что увеличение <...>