Biology 1 (2016 9) 6-20 ~ ~ ~ УДК 577.11 Biomedical Studies of Polyhydroxyalkanoates Ekaterina I. Shishatskaya* and Tatiana G. Volova Institute of Biophysics of SB RAS 50/50 Akademgorodok, Krasnoyarsk, 660036, Russia Siberian Federal University 79 Svobodny, Krasnoyarsk, 660041, Russia Received 16.11.2015, received in revised form 17.01.2016, accepted 02.03.2016 The paper describes research of biomedical applications of experimental polymer devices prepared from polyhydroxyalkanoates (PHAs) in the Institute of Biophysics SB RAS and Siberian Federal University (Krasnoyarsk, Russia) between 2000 and 2012. <...> The high-purity PHA specimens were investigated and then used to prepare surgical sutures, 2D and 3D dense and porous matrices, fully resorbable tubular stents, and polymer coatings. <...> The studies showed that PHAs were highly biocompatible with different tissues and their implantation for extended periods of time did not induce adverse responses of the blood system, cells, tissues, or the entire organism. <...> The authors proved that PHAs can be effectively used as prosthetic implants and bone-replacing implants. <...> All rights reserved * Corresponding author E-mail address: shishatskaya@inbox.ru # 6 # Ekaterina I. Shishatskaya and Tatiana G. Volova. <...> Biomedical Studies of Polyhydroxyalkanoates Биомедицинские исследования полигидроксиалканоатов Е. <...> The second most popular type of biodegradable polymers is polyhydroxyalkanoates (PHAs), which are more thermoplastic than PLA and have a less signifi cant effect on tissue pH, and whose in vivo resorption time is longer (Biopolymers, 2002; Williams and Martin, 2002; Volova, 2004; Sudesh, 2010; Chen, 2010;Volova et al., 2013a). <...> Many years of systematic studies have produced fundamental results on the functioning of the PHA cell cycle, factors determining polymer chemical structure, and interactions between the structure of a PHA and its physicochemical properties. <...> The study showed that by varying the composition of polyhydroxyalkanoates and their monomer fractions, one can produce materials and devices that would considerably differ properties. <...> Subsequent in their basic studies were aimed at construction of various special devices, implants, and polymer constructs for tissue engineering and reconstructive medicine (Shishatskaya, 2008, # 7 # Ekaterina I. Shishatskaya and Tatiana G. <...>