Материалы международной конференции «Молекулярная эпидемиология актуальных инфекций» HLA DRB1 GENE POLYMORPHISM IN TICK-BORNE ENCEPHALITIS PATIENTS IN LATVIA L. Kovalchuka1 , J. Eglite1 M. Zalite2,3, L. Viksna2,3 Immunogenetic laboratory 2 5 , I. Lucenko4 , A. Krumina2 , S. Gintere5 1Riga Stradi University, Clinical Immunology and Riga Stradi University, Infectology and Dermatology department 3Riga Eastern Clinical University Hospital, Infectology Center of Latvia 4Centre for Disease Prevention and Control of Latvia, Riga Riga Stradi University, Family Medicine department Introduction. <...> Tick-borne encephalitis in recent years is very actual disease, and the level of Tick-borne Disease in Latvian is one of the highest in Europe. <...> Compared to previous years, has increased tick activity and incidence. <...> To investigate the genetically determined ill with a tick-borne encephalitis predisposition to fall of different severity by analyzing HLA DRB1 genes in patients with different clinical forms. <...> The study included 64 patients of tick-borne encephalitis. <...> The diagnosis was confirmed and imposed Latvian Infectology Center. <...> Immunogenetic examinations were performed RSU Immunogenetic and Clinical Immunology Laboratory. <...> HLA genotyping performed with PCR method using primers with a mixture of DRB1 16 allele gene variants. <...> Patients were divided into three groups according to their situation and the seriousness of clinical forms. <...> Moderate course of tick-borne encephalitis, viral meningitis cases often occurring in a gene allele HLA II-DRB1 *04, whereas in severe cases, gait meningoencephalitis frequently detected gene allele HLADRBl *05. <...> If a man lives tick-endemic area, and immunogenetic investigation found the risk allele, then recommend vaccination against tick-borne encephalitis. <...> INVESTIGATIONS DQA1/DQB1 HAPLOTYPES IN PATIENTS WITH LYME BORRELIOSIS L. Kovalchuka1 , J. Eglite1 S. Gintere5 , M. Zalite2,3 , D. Kasjko1 , L. Viksna2,3 and Immunogenetic laboratory 2 5 1Riga Stradi University, Clinical Immunology Riga Stradi University, Infectology and Dermatology department 3Riga Eastern Clinical University Hospital, Infectology Center of Latvia 4Centre for Disease Prevention and Control of Latvia, Riga Riga Stradi University, Family Medicine department Introduction. <...> The genes encoding the HLA-DQ heterodimer molecules, DQA1 <...>