Sel’skokhozyaistvennaya Biologiya [Agricultural Biology], 2013, № 2, p. 40-45 UDK 636.4:636.064:[573.6.086.83+577.21]:577.175.322 BIOLOGICAL CHARACTERISTICS OF PIGS TRANSGENIC FOR HUMAN GROWTH HORMONE 1 All-Russia Research and Development Institute for Livestock Husbandry, RAAS, Dubrovitsy settlement 142132, Moscow province, Russia e-mail: n_zinovieva@mail.ru L.K. Ernst 1, N.A. Zinovieva1, N.A. Volkova1, A.Yu. <...> Filimonov2, I.A. Ralkov1, I.V. Gusev1, G. Brem3 3 Institute of Animal Husbandry and Animal Welfare of the University of Veterinary Medicine, Vienna A-1210, Austria e-mail: gottfried.brem@agrobiogen.de 2 N.I. Pirogov Russian National Research Medical University, Moscow 117997, Russia e-mail: aleks_ariah@mail.ru Received January 15, 2013 S umma r y The increase of growth hormone expression in pigs transgenic for WAP-hGH gene construct of F3 (non-pregnant and lactating sows) and F5 generations (young gilts in age of 5 and 9 months) was observed. <...> The alteration of some biochemical characteristics of blood serum in transgenic pigs comparing to control animals was detected. <...> The differences in correlation relationships between some biochemical characteristics of transgenic and control pigs were established. <...> One of prior targets of modern biotechnology is creation of transgenic animals that have predetermined productive and biological properties, or produce bioactive substances (1, 2). <...> Thus, C.W. Pittius et al. (4) detected mRNA of human tissue plasminogen activator in a tongue, kidneys, and salivary glands of transgenic mice. <...> The expression of human growth hormone (hGH) controlled by mouse WAP promoter of 2,6 kb length was found in the serum of lactating transgenic mice (5). <...> According W.H. Gьenzburg et al. (6), 40% transgenic mice – carriers of the integrated hGH gene construct with WAP-promoter of 2,4 kb length, showed the expression of the specific mRNA in salivary glands and testes. <...> Even in early period of research it was clear that interaction of an introduced gene construct and a host genome is more complex than just a simple summation of different determinants. <...> The object of research were pigs transgenic for human growth hormone gene construct controlled by the mouse WAP-promoter (WAP-hGH). <...> GH <...>