2016. 57, 1 – UDC 548.73:541.49:546.73 CRYSTAL STRUCTURE AND ANTITUMOR ACTIVITIES OF A DINUCLEAR COBALT(II) COMPLEX BASED ON MESO-1,2,3,4-TETRA(1H-BENZO[d]IMIDAZOL-2-YL)BUTANE Q.-W. Huang1, S.-X. Wang2, S.-G. Liu1, W.-Y. Su1, G.-B. Li1, Y.-M. He1 2Institute of Molecular Medicine, Medical School of Shenzhen University, Shenzhen, P. R. China Received September, 8, 2014 1School of Chemistry and Chemical Engineering, Lingnan Normal University, Development Center for New Materials Engineering and Technology in Universities of Guangdong, Zhanjiang, P. R. China E-mail: lsgui@sohu.com Revised November, 27, 2014 The [Co2(tbb)Cl4]4DMF complex, where tbb is meso-1,2,3,4-tetra(1H-benzo[d]imidazol-2yl)butane, is synthesized and characterized by single crystal X-ray diffraction. <...> Each cobalt(II) ion is formed by two tbb nitrogen atoms and two chloride ions. <...> The antiproliferative activities of the complex are screened by MTT assay against Eca109 cancer cells. <...> The complex exhibits inhibition on the growth of Eca109 cancer cells with IC50 of 22.16.7 M after 48 h treatment. <...> The cobalt complex has potential application in treatment of Eca109 cancer. <...> Intensive efforts have been made to develop new metal complexes that are effective against cancer cells either by changing the metal or the ligand. <...> Various transition metals combined with a variety of ligand classes, such as Schiff bases, amino acids, and extended polypyridine have been proposed to improve the efficacy of cancer treatment [ 6—10]. <...> Benzimidazole derivatives are important pharmacophores in drugs that display a diversity of pharmacological activities, such as anti-inflammatory, antioxidant, gastroprotective, and antiparasitic activities [11—14 ]. <...> In our recent study, some zinc complexes based on the organic containing benzimidazole group have been evaluated for in vitro anticancer activities [15—17 ]. <...> EXPERIMENTAL Materials and instrument. o-Phenylenediamine and meso-1,2,3,4-butane tetracarboxylic acid were purchased from ACROS Company. <...> The resulting dark brown solution was allowed to cool to room temperature and poured into water with vigorous stirring; a white solid formed, then it was filtered off, and the pure product <...>