The propenone bridge makes dihedral angles of 10.61(23) and 62.75(22) respectively, with 4-chlorophenyl and the [(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl group. <...> Chalcones or 1,3-diaryl-2-propen-1-ones belong to the flavonoid family. <...> The rising prevalence of multi-drug resistant gram-positive and gram-negative bacteria continues to provide impetus for the search for and discovery of novel antimicrobial agents active against these pathogens [ 1 ]. <...> A vast number of naturally occurring chalcones are polyhydroxylated in the aryl rings. <...> The radical quenching properties of the phenolic groups present in many chalcones have raised interest in using the compounds or chalcone-rich plant extracts as drugs or food preservatives. <...> Among many useful properties that chalcones have been reported to possess include anti-inflammatory, antimicrobial, antifungal, antioxidant, cytotoxic, HIV-1 protease inhibitory, tyrosinase inhibitory, antiprotozoal, antiulcer as well as other activities. <...> More importantly, chalcones have shown several anticancer activities as inhibitors of cancer cell proliferation, carcinogenesis and metastasis [ 2—6]. <...> Many chalcones have been assessed for their high antimalarial activity, which is probably a result of Michael addition of nucleophilic species to the double bond of the enone [ 2 ]. <...> Some chalcones demonstrated the ability to block voltage-dependent potassium channels. <...> Chalcones are also finding application as organic compounds reported to have NLO properties; chalcone derivatives are a recognized material because of their excellent blue light transmittance and good crystallization ability. <...> Owing to the importance of these flavonoid analogs, we report here the crystal structure of the title chalcone derivative. <...> The compound thus obtained was washed with water and recrystallised from ethanol. <...> A chemical diagram of compound 1 is shown in Scheme 1. <...> A brown crystal of title compound 1 with dimensions 0.350.30 0.25 mm was chosen for the data collection. <...> The data were collected with graphite-monochromated MoKh radiation (y = 0.71073 Е). <...> The maximum and minimum peaks and holes are 0.30 e/Е3 and –0.18 e/Е3 respectively. <...> The propenone bridge makes dihedral angles of 10.61(23) and 62.75(22) respectively with 4-chlorophenyl and the [(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl group. <...> The pyridine ring system and the benzene ring are oriented at a dihedral angle of 83.42(10). <...> The ethoxy group is coplanar with the phenyl <...>