ПРОДУКЦИЯ ФИТОТОКСИЧНОГО ПОЛИКЕТИДА СПАЙСФЕРОНА А ГРИБОМ PHOMA FUNGICOLA 3 Institute of Pharmaceutical Biology and Biotechnology of Heinrich-Heine University, Duesseldorf, Germany 1 Saratov State University, Saratov, Russia 2 Al-Azhar University, Assiut, Egypt 3 Институт фармацевтической биологии и биотехнологии при Университете Генриха Гейне, Дюссельдорф, Германия 1 Саратовский государственный университет, Саратов, Россия 2 Университет Аль-Захара, Ассиут, Египет 4 Mansoura University, Mansoura, Egypt 4 Университет г. <...> Мансура, Египет hassan_awad37@mail.ru The genus Phoma is distributed worldwide and known as bioactive group. <...> The investigated strain (AT100) was originally isolated from two apple sorts, Golden delicious and Berkutovka at Volga Region, Saratov city (Russia). <...> In particular, Phoma fungicola (AT100) was isolated from 21 of 28 different apple stem samples, ranging from 10 to 45 colony forming units per 10 cm stem surface. <...> This is further evidenced by both cotton blue staining and molecular biology analysis by internal transcribed spacer (ITS1), 18S rDNA gene sequencing which sharply confirmed it as Ph. fungicola, to which the accession number (KR184136) was given by GenBank. <...> Culturing Ph. fungicola (AT100) on sterilized solid rice medium afforded the compound spiciferone A as a major compound. <...> To the best of our knowledge, it is the first record to isolate spiciferone A from the genus Phoma. <...> Морфологические и молекулярные (ITS1) данные подтвердили принадлежность к данному таксону. <...> Fungal endophytes are well-known to live in many parts of plants including either aerial parts or even roots. <...> An existence of such fungal endophytes in plants is attributed to symbiotic relationships (Schulz, Boyle, 2005; Hyde, Soytong, 2008; Kumar et al., 2012; Waqas et al., 2014). <...> The main role of fungal endophytes is to improve a plant 35516, Egypt. growth (Schulz, Boyle, 2005). <...> Moreover, they directly affect the plant physiology and increase host plant immunity to be able to resist on stresses (Khan et al., 2011a). <...> This acquired plant resistance is caused mainly by endophytic <...>