Паразитология №2 2017 (962,50 руб.)

Studies have suggested an association between epilepsy and helminth infection, but a causal relationship is not established in many helminths, except perhaps with neurocysticercosis. <...> The aim of this review is to reveal details of specific mechanisms of the general helminths’ impact on the nervous system and the endocrine control level of physiological functions of the host organism. <...> According to literary data, the number of patients diagnosed with helminthiases shows a tendency for steady growth in the modern world (Garcia et al., 2014; Berkowitz et al., 2015; Morys et al., 2015). <...> The distribution of helminth infections is heterogeneous and estimates show that developing regions of the world have the highest prevalence of helminthiases. <...> Moreover, the authors of the cited publications underline that the localization of helminths in the human central nervous system can very often lead to serious mental illness (Carpio, Romo, 2014; Othman et al., 2014). <...> Firstly, helminthiasis neurological effects may be recorded even in cases where mechanical damage to the nervous tissue by body covers of the helminth does not occur. <...> Most likely, it is logical to consider the available data in this area of literature from the standpoint of one side of interaction aspects between parasite and host organisms (Escobedo et al., 2005; Bottasso, Morales-Montor, 2009; Escobedo et al., 2009). <...> Therefore, the aim of this review is to reveal details about the specific mechanisms of the helminths’ impact on the nervous system and the endocrine control level of physiological functions in the host organism. <...> NEUROLOGICAL EFFECTS OF HELMINTH INFECTIONS In our review we found it necessary to pay attention to the results of the recent experimental studies. <...> Since, according to some authors neuro-psychiatric disorders in humans in a chronic course of parasitic diseases, including helminth infections can be caused not only by direct neurotrophic effects of the parasite, but there again, resulting in damage to other organ systems: kidneys, liver, circulatory system, lungs, etc. (Moryъ et al., 2015). <...> It should be noted that the 98 comparison of clinical and experimental data led to some success in deciphering the pathogenic mechanisms of hippocampal sclerosis during neurocysticercosis that could lead to the development of epilepsy (Del Brutto et al., 2016). <...> However, the validity of the relationship <...>