Biology 1 (2016 9) 63-74 ~ ~ ~ УДК 615.462, 678 Properties and Biocompatibility of Poly-3-Hydroxybutyrate-co-3-Hydroxyvalerate/ Poly-ε-Caprolactone Blends Elena D. Nikolaevaa Anatoly N. Boyandina,b and Aleksey G. Sukovatiya *, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russia b Received 15.11.2015, received in revised form 29.01.2016, accepted 06.03.2016 Blends consisting of the poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) copolymer and polyε-caprolactone (PCL) were used to prepare polymer fi lms by casting solution technique. <...> The structure and physical-mechanical, and biological properties of the fi lms were examined as infl uenced by the ratios of the blend components. <...> The microstructure of the fi lms was determined by the dominant component: the fi lms had porous surface if the percentage of PHBV was higher than that of PCL and were relatively smooth if the dominant component was PCL. <...> The highest elongation at break (190-368 %) was exhibited by the fi lms prepared from the blends containing 5-25 % PHBV; at 25 % PHBV, local maxima of tensile strength (16 MPa) and Young’s modulus (529 MPa) were observed. <...> Biocompatibility of the fi lms prepared from the blends was studied in the culture of NIH 3T3 mouse fi broblast cells. <...> Results of SEM and DAPI staining, determination of the number of attached cells, and MTT assay showed the absence of cytotoxic effects and high cell adhesion and proliferation, which in some cases were higher than on fi lms prepared from pure PHBV and PCL. <...> Thus, PHBV/PCL blends are suitable materials for constructing cell scaffolds for tissue engineering and other reconstructive technologies. <...> All rights reserved * Corresponding author E-mail address: araneus@mail.ru aInstitute of Biophysics of SB RAS Siberian Federal University 79 Svobodny, Krasnoyarsk, 660041, Russia # 63 # Anatoly N. Boyandin, Elena D. Nikolaeva… Properties and Biocompatibility of Poly-3-Hydroxybutyrate… Свойства и биосовместимость смесей поли-3-гидроксибутирата-3-гидроксивалерата с поли-ε-капролактоном А. <...> Микроструктура пленок определялась преобладающим компонентом: пленки имели пористую поверхность, если содержание ПГБВ было выше, чем ПКЛ, и относительно гладкими при преобладании ПКЛ. <...> Наибольшее значение удлинения на разрыв (190-368 %) отмечалось для пленок, полученных из смесей с <...>